Code | CSB-YP639324FLF |
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Size | $436 |
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Recombinant full-length of Mature Staphylococcus aureus Alpha-hemolysin (hly) Protein (27-319 amino acids) with a 6xHis tag at the C-terminus was expressed in the yeast. SDS-PAGE analysis of the purified hly protein gave one band at 34–40 kDa of the target molecule. The purity of this hly protein is greater than 90%. The identification of the hly protein was validated by the LC-MS/MS Analysis. The delivery time is relatively short because the hly protein is in-stock.
Alpha-hemolysin (hly), also known as hla, is a single component toxin generated by Staphylococcus aureus, a potential human causative agent that can cause various acute and chronic infections. Hly plays an important role in the pathogenesis of Staphylococcus aureus. The interaction between hly and the specific cell receptor ADAM10 forms cylindrical transmembrane heptameric pores. The resulting pores allow the influx and efflux of ions and small molecules, ultimately leading to disruption of ionic equilibrium, osmotic expansion, and cell death.
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If there will be a link between the C-terminal and His-Tag? And do you do any assembly tests with the C-Terminal?
Yes, typically, there's a linker connecting the tag to the target protein. As for the "assembly tests with the C-Terminal" you mentioned, could you specify which tests you are referring to? We have previously developed multiple recombinant proteins with C-terminal His tags and have extensive experience in this area. If you can provide more information, we can offer detailed solutions.
KEGG: sao:SAOUHSC_01121
STRING: 93061.SAOUHSC_01121